Main Characters:
- Danny McCoy played by Josh Duhamel
- Ed Deline (2003-2007; Seasons 1-4) played by James Caan
- Delinda Deline played by Molly Sims
- Nessa Holt (2003-2005; Seasons 1 & 2) played by Marsha Thomason
- Samantha Jane Marquez played by Vanessa Marcil
- Mike Cannon played by James Lesure
- Mary Connell (2003-2007; Seasons 1-4) played by Nikki Cox
- AJ Cooper (2007-2008; Season 5) played by Tom Selleck
Recurring Characters:
- Piper Nielsen (2007-2008; Season 5) played by Camille Guaty
- Jillian Deline played by Cheryl Ladd
- Polly (2005-2008; Seasons 2-5) played by Suzanne Whang
- Mitch played by Mitch Longley
- Kathy Berson (2005-2008; Seasons 2-5) played by Rikki Klieman
- Monica Mancuso (2005; Season 3) played by Lara Flynn Boyle
- Casey Manning (2004-2007; Seasons 2-4) played by Dean Cain
- Luis Perez (2003-2005; Seasons 1 & 2) played by Guy Ecker
- Gunther (2004-2006; Seasons 2-3) played by Harry Groener
- Erika (2006-2007; Seasons 3 & 4) played by Anna Pheil
- Sarasvati Kumar (2004-2006; Seasons 2 & 3) played by Lakshmi Manchu
Celebrity Appearances: